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These include having a body mass index (BMI) of at least 27 and experiencing weight-related health issues such as type 2 diabetes, high cholesterol , or high blood pressure

When using a loading control, the right type of control must first be identified

doi: 10.1016/j.cca.2014.10.007 11 RaymanMP

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In particular, they are essential for the oxidative catabolism of long-chain fatty acids by shuttling them across the mitochondrial membrane from the cytosol into the mitochondrial matrix for oxidation and cellular energy production and thence for maintaining energy homeostasis in the human body